我自己有翻译了一些...
可能是第一次要学,,第一次要翻译
所以翻了不到三分之一就有困难了
希望好心人能帮我....因我们老师真的很刁
求求你们了　＠＠


大纲如下：


The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides corresponding to fragments from extracellular loops 1, 2 and 4 of the murine Pgp were coupled to polyethylene glycol-distearoylphosphatidylethanolamine and inserted into empty or monophosphoryl lipid A-containing liposomes. This formulation elicited specific antibodies which blocked Pgp-mediated efflux of doxorubicin, resulting in increased intracellular drug accumulation and subsequent potentiation of the cytotoxic effect of doxorubicin on multidrug-resistant P388 (P388R) cells. Previous immunizations with MDR1 peptides improved the efficiency of chemotherapy against P388R cells in vivo, with an increase of 83% of mice survival time. Overall, these results suggest that this approach can modulate Pgp activity by blocking drug efflux and may have clinical relevance as an alternative strategy to toxic chemosensitizers in drug-resistant cancer therapy.

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最佳解答:

临床使用化疗于癌症治疗目前是有限的，因为相关细胞膜上转运体过度过量表现所产生多种药物抗药性(MDR)发生，其中一个最被了解就是P-glycoprotein (Pgp)，其作用为将药物从肿瘤细胞逐出。为了克服Pgp所致多种药物抗药性，符合片段的合成氨基酸(synthetic peptides)从老鼠Pgp细胞外的环(extracellular loops)1, 2, 4接合到聚乙二醇-二硬酷酞磷酷酚乙醇胺(polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE))及插入空或者单磷酸类脂-A含脂质体。此种组合作法引起特殊抗体，其中可阻断Pgp导致排出Doxorubicin，因此提高细胞内药物累积及一连串增强Doxorubicin对多种药物抗药性P388( P388R)细胞的细胞毒性作用。
先前免疫接种多种药物抗药性1氨基酸，提高了化疗对抗P388R细胞在体内的效果，并且增加了83%老鼠的存活时间。
整体而言，这些结果显示，这种方法藉由调节Pgp的活性而阻断药物排出，并可以成为临床相关出现药物抗药性的癌症疗法中较具毒性化疗敏感剂，作为另一种替代策略趋势。

希望下次您可以自己试试看，常练习对您看原文书或期刊绝对有帮助!!!